Category: Research carousel
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Amino acid exchangeability: condensing data from mutation-scanning experiments
I just had to post the image below because it’s so cool. Here’s the backstory. A decade ago, Lev Yampolsky and I did a meta-analysis of mutation-scanning experiments– studies that systematically change amino acids in proteins, and measure the effects. Based on about 10,000 experimental exchanges, we computed an “EX” measure…
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The surprising case of origin-fixation models
In a recent QRB paper with David McCandlish, we review the form, origins, uses, and implications of models (e.g., the familiar K = 4Nus) that represent evolutionary change as a 2-step process of (1) the introduction of a new allele by mutation, followed by (2) its fixation or loss. What could…
Mutation and evolution 